ExplorEnz: EC 2.1.1.366

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2.1.1.366

Accepted name:

[histone H3]-N⁶,N⁶-dimethyl-lysine⁹ N-methyltransferase

Reaction:

S-adenosyl-L-methionine + a [histone H3]-N⁶,N⁶-dimethyl-L-lysine⁹ = S-adenosyl-L-homocysteine + a [histone H3]-N⁶,N⁶,N⁶-trimethyl-L-lysine⁹

Other name(s):

KMT1E (gene name); SETDB1 (gene name); KIAA0067 (gene name)

Systematic name:

S-adenosyl-L-methionine:[histone H3]-N⁶,N⁶-dimethyl-L-lysine⁹ N⁶-methyltransferase

Comments:

The enzyme methylates only dimethylated lysine⁹ of histone H3 (H3K9), forming the trimethylated form. This modification influences the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. The enzyme is highly upregulated in Huntington disease patients. cf. EC 2.1.1.367, [histone H3]-lysine⁹ N-methyltransferase, and EC 2.1.1.368, [histone H3]-lysine⁹ N-dimethyltransferase, and EC 2.1.1.355, [histone H3]-lysine⁹ N-trimethyltransferase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Yang, L., Xia, L., Wu, D.Y., Wang, H., Chansky, H.A., Schubach, W.H., Hickstein, D.D. and Zhang, Y. Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene 21 (2002) 148–152. [PMID: 11791185]
2.	Wang, H., An, W., Cao, R., Xia, L., Erdjument-Bromage, H., Chatton, B., Tempst, P., Roeder, R.G. and Zhang, Y. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol. Cell 12 (2003) 475–487. [PMID: 14536086]
3.	Pinheiro, I., Margueron, R., Shukeir, N., Eisold, M., Fritzsch, C., Richter, F.M., Mittler, G., Genoud, C., Goyama, S., Kurokawa, M., Son, J., Reinberg, D., Lachner, M. and Jenuwein, T. Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell 150 (2012) 948–960. [PMID: 22939622]

[EC 2.1.1.366 created 2020]