ExplorEnz: EC 2.1.1.345

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2.1.1.345

Accepted name:

psilocybin synthase

Reaction:

2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = 2 S-adenosyl-L-homocysteine + psilocybin (overall reaction)
(1a) S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine 4-phosphate
(1b) S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine 4-phosphate = S-adenosyl-L-homocysteine + psilocybin

For diagram of psilocybin biosynthesis, click here

Glossary:

psilocybin = 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl phosphate

Other name(s):

PsiM

Systematic name:

S-adenosyl-L-methionine:4-hydroxytryptamine-4-phosphate N,N-dimethyltransferase

Comments:

Isolated from the fungus Psilocybe cubensis. The product, psilocybin, is a psychoactive compound.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Fricke, J., Blei, F. and Hoffmeister, D. Enzymatic synthesis of psilocybin. Angew. Chem. Int. Ed. Engl. 56 (2017) 12352–12355. [DOI] [PMID: 28763571]

[EC 2.1.1.345 created 2017]