EC |
2.1.1.304 |
Accepted name: |
L-tyrosine C3-methyltransferase |
Reaction: |
S-adenosyl-L-methionine + L-tyrosine = S-adenosyl-L-homocysteine + 3-methyl-L-tyrosine |
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For diagram of saframycin biosynthesis, click here |
Other name(s): |
SfmM2; SacF |
Systematic name: |
S-adenosyl-L-methionine:L-tyrosine C3-methyltransferase |
Comments: |
The enzyme from the bacterium Streptomyces lavendulae is involved in biosynthesis of saframycin A, a potent antitumor antibiotic that belongs to the tetrahydroisoquinoline family. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Tang, M.C., Fu, C.Y. and Tang, G.L. Characterization of SfmD as a heme peroxidase that catalyzes the regioselective hydroxylation of 3-methyltyrosine to 3-hydroxy-5-methyltyrosine in saframycin A biosynthesis. J. Biol. Chem. 287 (2012) 5112–5121. [DOI] [PMID: 22187429] |
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[EC 2.1.1.304 created 2014] |
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