| EC |
2.1.1.299 |
| Accepted name: |
protein N-terminal monomethyltransferase |
| Reaction: |
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein] |
| Other name(s): |
NRMT2 (gene name); METTL11B (gene name); N-terminal monomethylase |
| Systematic name: |
S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase |
| Comments: |
This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Petkowski, J.J., Bonsignore, L.A., Tooley, J.G., Wilkey, D.W., Merchant, M.L., Macara, I.G. and Schaner Tooley, C.E. NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1. Biochem. J. 456 (2013) 453–462. [DOI] [PMID: 24090352] |
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| [EC 2.1.1.299 created 2014] |
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