EC |
2.1.1.264 |
Accepted name: |
23S rRNA (guanine2069-N7)-methyltransferase |
Reaction: |
S-adenosyl-L-methionine + guanine2069 in 23S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA |
Other name(s): |
rlmK (gene name); 23S rRNA m7G2069 methyltransferase |
Systematic name: |
S-adenosyl-L-methionine:23S rRNA (guanine2069-N7)-methyltransferase |
Comments: |
The enzyme specifically methylates guanine2069 at position N7 in 23S rRNA. In γ-proteobacteria the enzyme also catalyses EC 2.1.1.173, 23S rRNA (guanine2445-N2)-methyltransferase, while in β-proteobacteria the activities are carried out by separate proteins [1]. The enzyme from the γ-proteobacterium Escherichia coli has RNA unwinding activity as well [1]. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
References: |
1. |
Kimura, S., Ikeuchi, Y., Kitahara, K., Sakaguchi, Y., Suzuki, T. and Suzuki, T. Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activity. Nucleic Acids Res. 40 (2012) 4071–4085. [DOI] [PMID: 22210896] |
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[EC 2.1.1.264 created 2012] |
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