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Your query returned 1 entry. Printable version
EC | 2.1.1.251 | ||||||
Accepted name: | methylated-thiol—coenzyme M methyltransferase | ||||||
Reaction: | methanethiol + CoM = methyl-CoM + hydrogen sulfide (overall reaction) (1a) methanethiol + a [Co(I) methylated-thiol-specific corrinoid protein] = a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + hydrogen sulfide (1b) a [methyl-Co(III) methylated-thiol-specific corrinoid protein] + CoM = methyl-CoM + a [Co(I) methylated-thiol-specific corrinoid protein] |
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Glossary: | CoM = coenzyme M = 2-sulfanylethane-1-sulfonate = 2-mercaptoethanesulfonate (deprecated) | ||||||
Other name(s): | mtsA (gene name) | ||||||
Systematic name: | methylated-thiol:CoM methyltransferase | ||||||
Comments: | The enzyme, which is involved in methanogenesis from methylated thiols, such as methane thiol, dimethyl sulfide, and 3-(methylsulfanyl)propanoate, catalyses two successive steps - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to CoM. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90, methanol—corrinoid protein Co-methyltransferase, and EC 2.1.1.246, [methyl-Co(III) methanol-specific corrinoid protein]—coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
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