Accepted name: tRNA (cytidine56-2′-O)-methyltransferase
Reaction: S-adenosyl-L-methionine + cytidine56 in tRNA = S-adenosyl-L-homocysteine + 2′-O-methylcytidine56 in tRNA
Other name(s): aTrm56; tRNA ribose 2′-O-methyltransferase aTrm56; PAB1040 (gene name)
Systematic name: S-adenosyl-L-methionine:tRNA (cytidine56-2′-O)-methyltransferase
Comments: The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2′-O-ribose methylation of cytidine at position 56 in tRNA transcripts.
1.  Renalier, M.H., Joseph, N., Gaspin, C., Thebault, P. and Mougin, A. The Cm56 tRNA modification in archaea is catalyzed either by a specific 2′-O-methylase, or a C/D sRNP. RNA 11 (2005) 1051–1063. [PMID: 15987815]
2.  Kuratani, M., Bessho, Y., Nishimoto, M., Grosjean, H. and Yokoyama, S. Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2′-O-methylcytidine at position 56 of tRNA. J. Mol. Biol. 375 (2008) 1064–1075. [PMID: 18068186]
[EC created 2011]

Data © 2001–2019 IUBMB
Web site © 2005–2019 Andrew McDonald