ExplorEnz: EC 2.1.1.204

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2.1.1.204

Accepted name:

tRNA (cytosine³⁸-C⁵)-methyltransferase

Reaction:

S-adenosyl-L-methionine + cytosine³⁸ in tRNA = S-adenosyl-L-homocysteine + 5-methylcytosine³⁸ in tRNA

Other name(s):

hDNMT2 (gene name); DNMT2 (gene name); TRDMT1 (gene name)

Systematic name:

S-adenosyl-L-methionine:tRNA (cytosine³⁸-C⁵)-methyltransferase

Comments:

The eukaryotic enzyme catalyses methylation of cytosine³⁸ in the anti-codon loop of tRNA^Asp(GTC), tRNA^Val(AAC) and tRNA^Gly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Goll, M.G., Kirpekar, F., Maggert, K.A., Yoder, J.A., Hsieh, C.L., Zhang, X., Golic, K.G., Jacobsen, S.E. and Bestor, T.H. Methylation of tRNA^Asp by the DNA methyltransferase homolog Dnmt2. Science 311 (2006) 395–398. [DOI] [PMID: 16424344]
2.	Jurkowski, T.P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G. and Jeltsch, A. Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA 14 (2008) 1663–1670. [DOI] [PMID: 18567810]
3.	Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M. and Lyko, F. RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. Genes Dev. 24 (2010) 1590–1595. [DOI] [PMID: 20679393]

[EC 2.1.1.204 created 1976 as EC 2.1.1.29, part transferred 2011 to EC 2.1.1.204]