| EC |
2.1.1.131 |
| Accepted name: |
precorrin-3B C17-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 |
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For diagram of corrin biosynthesis (part 3), click here and for mechanism of reaction, click here |
| Other name(s): |
precorrin-3 methyltransferase; CobJ |
| Systematic name: |
S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase |
| Comments: |
The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. See EC 2.1.1.272, cobalt-factor III methyltransferase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 152787-64-9 |
| References: |
| 1. |
Scott, A.I., Roessner, C.A., Stolowich, N.J., Spencer, J.B., Min, C. and Ozaki, S.I. Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group. FEBS Lett. 331 (1993) 105–108. [DOI] [PMID: 8405386] |
| 2. |
Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F. Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans. J. Bacteriol. 175 (1993) 7430–7440. [DOI] [PMID: 8226690] |
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| [EC 2.1.1.131 created 1999] |
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