| EC |
1.8.98.8 |
| Accepted name: |
thioredoxin-disulfide reductase (factor 420-dependent) |
| Reaction: |
thioredoxin + an oxidized factor 420 = thioredoxin disulfide + a reduced factor 420 |
| Other name(s): |
F420-dependent thioredoxin-disulfide reductase; deazaflavin-dependent flavin-containing thioredoxin reductase; (coenzyme F420)-dependent thioredoxin-disulfide reductase |
| Systematic name: |
thioredoxin:factor 420 oxidoreductase |
| Comments: |
A flavoprotein (FAD). The enzyme is found only in methanogenic archaea living in deep-sea volcanoes, and requires high partial pressure of hydrogen, which effects the reducing potential of the F420/F420H2 pair. cf. EC 1.8.1.9, thioredoxin-disulfide reductase (NADPH). |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Susanti, D., Loganathan, U. and Mukhopadhyay, B. A novel F420-dependent thioredoxin reductase gated by low potential FAD: a tool for redox regulation in an anaerobe. J. Biol. Chem. 291 (2016) 23084–23100. [DOI] [PMID: 27590343] |
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| [EC 1.8.98.8 created 2025] |
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