ExplorEnz: EC 1.7.1.16

Your query returned 1 entry. Printable version

1.7.1.16

Accepted name:

nitrobenzene nitroreductase

Reaction:

N-phenylhydroxylamine + 2 NADP⁺ + H₂O = nitrobenzene + 2 NADPH + 2 H⁺ (overall reaction)
(1a) N-phenylhydroxylamine + NADP⁺ = nitrosobenzene + NADPH + H⁺
(1b) nitrosobenzene + NADP⁺ + H₂O = nitrobenzene + NADPH + H⁺

Other name(s):

cnbA (gene name)

Systematic name:

N-phenylhydroxylamine:NADP⁺ oxidoreductase

Comments:

Contains FMN. The enzyme, characterized from Pseudomonas species, catalyses two successive reductions of nitrobenzene, via a nitrosobenzene intermediate. It is also active on 1-chloro-4-nitrobenzene.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Somerville, C.C., Nishino, S.F. and Spain, J.C. Purification and characterization of nitrobenzene nitroreductase from Pseudomonas pseudoalcaligenes JS45. J. Bacteriol. 177 (1995) 3837–3842. [DOI] [PMID: 7601851]
2.	Wu, J.F., Jiang, C.Y., Wang, B.J., Ma, Y.F., Liu, Z.P. and Liu, S.J. Novel partial reductive pathway for 4-chloronitrobenzene and nitrobenzene degradation in Comamonas sp. strain CNB-1. Appl. Environ. Microbiol. 72 (2006) 1759–1765. [DOI] [PMID: 16517619]

[EC 1.7.1.16 created 2017]