| EC |
1.7.1.12 |
| Accepted name: |
N-hydroxy-2-acetamidofluorene reductase |
| Reaction: |
2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+ |
| Other name(s): |
N-hydroxy-2-acetylaminofluorene reductase; NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase |
| Systematic name: |
2-acetamidofluorene:NAD(P)+ oxidoreductase |
| Comments: |
Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 99890-08-1 |
| References: |
| 1. |
Gutmann, H.R. and Erickson, R.R. The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction. J. Biol. Chem. 244 (1969) 1729–1740. [PMID: 5780838] |
| 2. |
Kitamura, S. and Tatsumi, K. Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol. Biochem. Biophys. Res. Commun. 133 (1985) 67–74. [DOI] [PMID: 4074379] |
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| [EC 1.7.1.12 created 1989 as EC 1.6.6.13, transferred 2002 to EC 1.7.1.12] |
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