ExplorEnz: EC 1.6.3.4

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1.6.3.4

Accepted name:

NADH oxidase (H₂O-forming)

Reaction:

2 NADH + 2 H⁺ + O₂ = 2 NAD⁺ + 2 H₂O

Other name(s):

H₂O-forming NADH oxidase; Nox-2

Systematic name:

NADH:oxygen oxidoreductase (H₂O-forming)

Comments:

A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H₂O-forming enzyme and a H₂O₂-forming enzyme (cf. EC 1.6.3.3, NADH oxidase (H₂O₂-forming)) [1].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Schmidt, H.L., Stocklein, W., Danzer, J., Kirch, P. and Limbach, B. Isolation and properties of an H₂O-forming NADH oxidase from Streptococcus faecalis. Eur. J. Biochem. 156 (1986) 149–155. [DOI] [PMID: 3082630]
2.	Higuchi, M., Shimada, M., Yamamoto, Y., Hayashi, T., Koga, T. and Kamio, Y. Identification of two distinct NADH oxidases corresponding to H₂O₂-forming oxidase and H₂O-forming oxidase induced in Streptococcus mutans. J. Gen. Microbiol. 139 (1993) 2343–2351. [DOI] [PMID: 8254304]
3.	Matsumoto, J., Higuchi, M., Shimada, M., Yamamoto, Y. and Kamio, Y. Molecular cloning and sequence analysis of the gene encoding the H₂O-forming NADH oxidase from Streptococcus mutans. Biosci. Biotechnol. Biochem. 60 (1996) 39–43. [DOI] [PMID: 8824824]
4.	Kawasaki, S., Ishikura, J., Chiba, D., Nishino, T. and Niimura, Y. Purification and characterization of an H₂O-forming NADH oxidase from Clostridium aminovalericum: existence of an oxygen-detoxifying enzyme in an obligate anaerobic bacteria. Arch. Microbiol. 181 (2004) 324–330. [DOI] [PMID: 15014929]
5.	Zhang, Y.W., Tiwari, M.K., Gao, H., Dhiman, S.S., Jeya, M. and Lee, J.K. Cloning and characterization of a thermostable H₂O-forming NADH oxidase from Lactobacillus rhamnosus. Enzyme Microb. Technol. 50 (2012) 255–262. [DOI] [PMID: 22418266]

[EC 1.6.3.4 created 2013]