| EC |
1.5.99.16 |
| Accepted name: |
2-(methylaminoethyl)phosphonate dehydrogenase (acceptor) |
| Reaction: |
2-(methylaminoethyl)phosphonate + acceptor + H2O = phosphonoacetaldehyde + methylamine + reduced acceptor |
| Other name(s): |
pbfC (gene name); N-methyl-2-aminoethylphosphonate dehydrogenase (acceptor) |
| Systematic name: |
2-(methylaminoethyl)phosphonate:acceptor oxidoreductase (phosphonoacetaldehyde-forming) |
| Comments: |
Contains FAD. The enzyme from the bacterium Azospirillum sp. B510 reacts about tenfold less efficiently with 2-(ethylaminoethyl)phosphonate and about 400-fold less efficiently with (2-aminoethyl)phosphonate. Oxygen is used poorly as an electron acceptor (at least 50-fold less efficiently than the artificial acceptor DCPIP). The physiological electron acceptor is unknown. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Zangelmi, E., Ruffolo, F., Dinhof, T., Gerdol, M., Malatesta, M., Chin, J.P., Rivetti, C., Secchi, A., Pallitsch, K. and Peracchi, A. Deciphering the role of recurrent FAD-dependent enzymes in bacterial phosphonate catabolism. iScience 26:108108 (2023). [DOI] [PMID: 37876809] |
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| [EC 1.5.99.16 created 2024] |
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