ExplorEnz: EC 1.5.98.3

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1.5.98.3

Accepted name:

coenzyme F₄₂₀:methanophenazine dehydrogenase

Reaction:

reduced coenzyme F₄₂₀ + methanophenazine = oxidized coenzyme F₄₂₀ + dihydromethanophenazine

Glossary:

methanophenazine = 2-{[(6E,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl]oxy}phenazine
dihydromethanophenazine = 2-{[(6E,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl]oxy}-5,10-dihydrophenazine

Other name(s):

F₄₂₀H₂ dehydrogenase; fpoBCDIF (gene names)

Systematic name:

reduced coenzyme F₄₂₀:methanophenazine oxidoreductase

Comments:

The enzyme, found in some methanogenic archaea, is responsible for the reoxidation of coenzyme F₄₂₀, which is reduced during methanogenesis, and for the reduction of methanophenazine to dihydromethanophenazine, which is required by EC 1.8.98.1, dihydromethanophenazine:CoB-CoM heterodisulfide reductase. The enzyme is membrane-bound, and is coupled to proton translocation across the cytoplasmic membrane, generating a proton motive force that is used for ATP generation.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Brodersen, J., Gottschalk, G. and Deppenmeier, U. Membrane-bound F₄₂₀H₂-dependent heterodisulfide reduction in Methanococcus volta. Arch. Microbiol. 171 (1999) 115–121. [PMID: 9914308]
2.	Baumer, S., Ide, T., Jacobi, C., Johann, A., Gottschalk, G. and Deppenmeier, U. The F₄₂₀H₂ dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases. J. Biol. Chem. 275 (2000) 17968–17973. [DOI] [PMID: 10751389]
3.	Deppenmeier, U. The membrane-bound electron transport system of Methanosarcina species. J. Bioenerg. Biomembr. 36 (2004) 55–64. [PMID: 15168610]
4.	Abken H. J. and Deppenmeier, U. Purification and properties of an F₄₂₀H₂ dehydrogenase from Methanosarcina mazei Gö1. FEMS Microbiol. Lett. 154 (2006) 231–237.

[EC 1.5.98.3 created 2017]