| EC |
1.5.1.47 |
| Accepted name: |
dihydromethanopterin reductase [NAD(P)+] |
| Reaction: |
5,6,7,8-tetrahydromethanopterin + NAD(P)+ = 7,8-dihydromethanopterin + NAD(P)H + H+ |
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For diagram of methanopterin biosynthesis (part 4), click here |
| Other name(s): |
DmrA; H2MPT reductase; 5,6,7,8-tetrahydromethanopterin 5,6-oxidoreductase; dihydromethanopterin reductase |
| Systematic name: |
5,6,7,8-tetrahydromethanopterin:NAD(P)+ 5,6-oxidoreductase |
| Comments: |
The enzyme, characterized from the bacterium Methylobacterium extorquens, is involved in biosynthesis of dephospho-tetrahydromethanopterin. The specific activity with NADH is 15% of that with NADPH at the same concentration [1]. It does not reduce 7,8-dihydrofolate (cf. EC 1.5.1.3, dihydrofolate reductase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Caccamo, M.A., Malone, C.S. and Rasche, M.E. Biochemical characterization of a dihydromethanopterin reductase involved in tetrahydromethanopterin biosynthesis in Methylobacterium extorquens AM1. J. Bacteriol. 186 (2004) 2068–2073. [DOI] [PMID: 15028691] |
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| [EC 1.5.1.47 created 2013, modified 2014] |
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