Accepted name: FAD reductase [NAD(P)H]
Reaction: FADH2 + NAD(P)+ = FAD + NAD(P)H + H+
Other name(s): GTNG_3158 (gene name)
Systematic name: FADH2:NAD(P)+ oxidoreductase
Comments: This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and EC, anthranilate 3-monooxygenase (FAD). It can reduce either FAD or flavin mononucleotide (FMN) but prefers FAD. The enzyme has a slight preference for NADPH as acceptor. cf. EC, FAD reductase (NADH).
1.  Liu, X., Dong, Y., Li, X., Ren, Y., Li, Y., Wang, W., Wang, L. and Feng, L. Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2. Microbiology 156 (2010) 589–595. [PMID: 19942660]
[EC created 2012]

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