The Enzyme Database

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EC 1.5.1.32     
Accepted name: vomilenine reductase
Reaction: (2R)-1,2-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+
For diagram of ajmaline, vinorine, vomilenine and raucaffricine biosynthesis, click here
Other name(s): VR (gene name); 1,2-dihydrovomilenine:NADP+ oxidoreductase
Systematic name: (2R)-1,2-dihydrovomilenine:NADP+ oxidoreductase
Comments: The enzyme, characterized from the plant Rauvolfia serpentina, participates in the ajmaline biosynthesis pathway.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 462127-03-3
References:
1.  von Schumann, G., Gao, S. and Stöckigt, J. Vomilenine reductase - a novel enzyme catalyzing a crucial step in the biosynthesis of the therapeutically applied antiarrhythmic alkaloid ajmaline. J. Bioorg. Med. Chem. 10 (2002) 1913–1918. [DOI] [PMID: 11937349]
2.  Guo, J., Gao, D., Lian, J. and Qu, Y. De novo biosynthesis of antiarrhythmic alkaloid ajmaline. Nat. Commun. 15:457 (2024). [DOI] [PMID: 38212296]
[EC 1.5.1.32 created 2002, modified 2024]
 
 


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