The Enzyme Database

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Accepted name: berberine reductase
Reaction: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+
For diagram of canadine biosynthesis, click here
Other name(s): (R)-canadine synthase
Systematic name: (R)-tetrahydroberberine:NADP+ oxidoreductase
Comments: Involved in alkaloid biosynthesis in Corydalis cava to give (R)-canadine with the opposite configuration to the precursor of berberine (see EC tetrahydroberberine oxidase). Also acts on 7,8-dihydroberberine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Bauer, W. and Zenk, M.H. Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro. Tetrahedron Lett. 32 (1991) 487–490.
[EC created 2002]

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