| EC |
1.4.1.12 |
| Accepted name: |
2,4-diaminopentanoate dehydrogenase |
| Reaction: |
(2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+ |
| Other name(s): |
2,4-diaminopentanoic acid C4 dehydrogenase |
| Systematic name: |
(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating) |
| Comments: |
Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, CAS registry number: 39346-26-4 |
| References: |
| 1. |
Somack, R. and Costilow, R.N. 2,4-Diaminopentanoic acid C4 dehydrogenase. Purification and properties of the protein. J. Biol. Chem. 248 (1973) 385–388. [PMID: 4684685] |
| 2. |
Stadtman, T.C. Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase). Adv. Enzymol. Relat. Areas Mol. Biol. 38 (1973) 441–445. |
| 3. |
Tsuda, Y. and Friedmann, H.C. Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide. J. Biol. Chem. 245 (1970) 5914–5926. [PMID: 4394942] |
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| [EC 1.4.1.12 created 1976, modified 2017] |
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