| EC |
1.3.99.23 |
| Accepted name: |
all-trans-retinol 13,14-reductase |
| Reaction: |
all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor |
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For diagram of biosynthesis of retinal and derivatives, click here |
| Other name(s): |
retinol saturase; RetSat; (13,14)-all-trans-retinol saturase; all-trans-retinol:all-trans-13,14-dihydroretinol saturase |
| Systematic name: |
all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase |
| Comments: |
The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 879291-21-1 |
| References: |
| 1. |
Moise, A.R., Kuksa, V., Imanishi, Y. and Palczewski, K. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J. Biol. Chem. 279 (2004) 50230–50242. [DOI] [PMID: 15358783] |
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| [EC 1.3.99.23 created 2005] |
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