ExplorEnz: EC 1.3.8.17

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1.3.8.17

Accepted name:

dehydro coenzyme F₄₂₀ reductase

Reaction:

oxidized coenzyme F₄₂₀-0 + FMN = dehydro coenzyme F₄₂₀-0 + FMNH₂

Glossary:

dehydro coenzyme F₄₂₀-0 = 2-{[5-deoxy-5-(8-hydroxy-2,4-dioxopyrimidino[4,5-b]quinolin-10(2H)-yl)-L-ribityloxy]hydroxyphosphoryloxy}prop-2-enoate

Other name(s):

fbiB (gene name)

Systematic name:

oxidized coenzyme F₄₂₀-0:FMN oxidoreductase

Comments:

This enzyme is involved in the biosynthesis of coenzyme F₄₂₀, a redox-active cofactor found in all methanogenic archaea, as well as some eubacteria. In some eubacteria the enzyme is multifunctional, also catalysing the activities of EC 6.3.2.31, coenzyme F₄₂₀-0:L-glutamate ligase, and EC 6.3.2.34, coenzyme F₄₂₀-1:γ-L-glutamate ligase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Bashiri, G., Antoney, J., Jirgis, E.NM., Shah, M.V., Ney, B., Copp, J., Stuteley, S.M., Sreebhavan, S., Palmer, B., Middleditch, M., Tokuriki, N., Greening, C., Scott, C., Baker, E.N. and Jackson, C.J. A revised biosynthetic pathway for the cofactor F₄₂₀ in prokaryotes. Nat. Commun. 10:1558 (2019). [DOI] [PMID: 30952857]

[EC 1.3.8.17 created 2021]