| EC |
1.3.8.12 |
| Accepted name: |
(2S)-methylsuccinyl-CoA dehydrogenase |
| Reaction: |
(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein = 2-methylfumaryl-CoA + reduced electron-transfer flavoprotein |
| Glossary: |
2-methylfumaryl-CoA = (E)-3-carboxy-2-methylprop-2-enoyl-CoA |
| Other name(s): |
Mcd |
| Systematic name: |
(2S)-methylsuccinyl-CoA:electron-transfer flavoprotein oxidoreductase |
| Comments: |
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Erb, T.J., Fuchs, G. and Alber, B.E. (2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Mol. Microbiol. 73 (2009) 992–1008. [DOI] [PMID: 19703103] |
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| [EC 1.3.8.12 created 2015] |
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