| EC |
1.3.3.18 |
| Accepted name: |
5-bromoskatole synthase |
| Reaction: |
5-bromo-L-tryptophan + O2 = 5-bromoskatole + cyanide + CO2 + H2O2 |
| Glossary: |
5-bromoskatole = 5-bromo-3-methyl-1H-indole |
| Other name(s): |
SktA; skatole synthase |
| Systematic name: |
5-bromo-L-tryptophan:oxygen oxidoreductase (5-bromoskatole forming) |
| Comments: |
The enzyme, isolated from the cyanobacterium Nostoc punctiforme, requires Fe(II). It is an oxygen-dependent diiron oxidase. The C-2 hydrogen of tryptophan is transferred in the reaction to the methyl group of skatole. The enzyme also acts on L-tryptophan, forming skatole. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Adak, S., Calderone, L.A., Krueger, A., Pandelia, M.E. and Moore, B.S. Single-enzyme conversion of tryptophan to skatole and cyanide expands the mechanistic competence of diiron oxidases. J. Am. Chem. Soc. 147 (2025) 6326–6331. [DOI] [PMID: 39939147] |
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| [EC 1.3.3.18 created 2025] |
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