The Enzyme Database

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Accepted name: fumarate reductase (cytochrome)
Reaction: succinate + 2 ferricytochrome c = fumarate + 2 ferrocytochrome c
Other name(s): fccA (gene name); fcc3 (gene name); flavocytochrome c3
Systematic name: succinate:ferricytochrome-c oxidoreductase
Comments: Contains a non-covalently bound FAD cofactor and four heme c groups. The enzyme, characterized from the bacterium Shewanella frigidimarina, is a soluble periplasmic protein that functions as a terminal electron acceptor during anaerobic growth. The direct electron donor is the membrane-bound tetraheme c-type cytochrome CymA (EC, quinol—cytochrome-c reductase), which receives the electrons from the membrane quinol pool.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Pealing, S.L., Black, A.C., Manson, F.D., Ward, F.B., Chapman, S.K. and Reid, G.A. Sequence of the gene encoding flavocytochrome c from Shewanella putrefaciens: a tetraheme flavoenzyme that is a soluble fumarate reductase related to the membrane-bound enzymes from other bacteria. Biochemistry 31 (1992) 12132–12140. [DOI] [PMID: 1333793]
2.  Pealing, S.L., Cheesman, M.R., Reid, G.A., Thomson, A.J., Ward, F.B. and Chapman, S.K. Spectroscopic and kinetic studies of the tetraheme flavocytochrome c from Shewanella putrefaciens NCIMB400. Biochemistry 34 (1995) 6153–6158. [DOI] [PMID: 7742319]
3.  Gordon, E.HJ., Pealing, S.L., Chapman, S.K., Ward, F.B. and Reid, G.A. Physiological function and regulation of flavocytochrome c3, the soluble fumarate reductase from Shewanella putrefaciens NCIMB 400. Microbiology (Reading) 144 (1998) 937–945. [DOI] [PMID: 9579067]
4.  Doherty, M.K., Pealing, S.L., Miles, C.S., Moysey, R., Taylor, P., Walkinshaw, M.D., Reid, G.A. and Chapman, S.K. Identification of the active site acid/base catalyst in a bacterial fumarate reductase: a kinetic and crystallographic study. Biochemistry 39 (2000) 10695–10701. [DOI] [PMID: 10978153]
5.  Reid, G.A., Miles, C.S., Moysey, R.K., Pankhurst, K.L. and Chapman, S.K. Catalysis in fumarate reductase. Biochim. Biophys Acta 1459 (2000) 310–315. [DOI] [PMID: 11004445]
6.  Schwalb, C., Chapman, S.K. and Reid, G.A. The membrane-bound tetrahaem c-type cytochrome CymA interacts directly with the soluble fumarate reductase in Shewanella. Biochem Soc Trans. 30 (2002) 658–662. [DOI] [PMID: 12196158]
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