ExplorEnz: EC 1.3.1.94

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1.3.1.94

Accepted name:

polyprenal reductase

Reaction:

a dolichal + NADP⁺ = a ditrans,polycis-polyprenal + NADPH + H⁺

Other name(s):

SRD5A3 (gene name); DFG10 (gene name); polyprenol reductase (incorrect); ditrans,polycis-dolichol:NADP⁺ 2,3-oxidoreductase (incorrect)

Systematic name:

dolichal:NADP⁺ 2,3-oxidoreductase

Comments:

The enzyme, isolated from human fetal brain tissue but present in all eukaryotes, catalyses the reduction of the terminal double bond next to the aldehyde group in ditrans,polycis-polyprenal, as part of the pathway that produces dolichol. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Sagami, H., Kurisaki, A. and Ogura, K. Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver. J. Biol. Chem. 268 (1993) 10109–10113. [DOI] [PMID: 8486680]
2.	Cantagrel, V., Lefeber, D.J., Ng, B.G., Guan, Z., Silhavy, J.L., Bielas, S.L., Lehle, L., Hombauer, H., Adamowicz, M., Swiezewska, E., De Brouwer, A.P., Blumel, P., Sykut-Cegielska, J., Houliston, S., Swistun, D., Ali, B.R., Dobyns, W.B., Babovic-Vuksanovic, D., van Bokhoven, H., Wevers, R.A., Raetz, C.R., Freeze, H.H., Morava, E., Al-Gazali, L. and Gleeson, J.G. SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142 (2010) 203–217. [DOI] [PMID: 20637498]
3.	Wilson, M.P., Kentache, T., Althoff, C.R., Schulz, C., de Bettignies, G., Mateu Cabrera, G., Cimbalistiene, L., Burnyte, B., Yoon, G., Costain, G., Vuillaumier-Barrot, S., Cheillan, D., Rymen, D., Rychtarova, L., Hansikova, H., Bury, M., Dewulf, J.P., Caligiore, F., Jaeken, J., Cantagrel, V., Van Schaftingen, E., Matthijs, G., Foulquier, F. and Bommer, G.T. A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis. Cell (2024) . [DOI] [PMID: 38821050]

[EC 1.3.1.94 created 2012, modified 2024]