ExplorEnz: EC 1.3.1.91

Your query returned 1 entry. Printable version

1.3.1.91

Accepted name:

tRNA-dihydrouridine²⁰ synthase [NAD(P)⁺]

Reaction:

5,6-dihydrouracil²⁰ in tRNA + NAD(P)⁺ = uracil²⁰ in tRNA + NAD(P)H + H⁺

Other name(s):

Dus2p; tRNA-dihydrouridine synthase 2

Systematic name:

tRNA-5,6-dihydrouracil²⁰:NAD(P)⁺ oxidoreductase

Comments:

A flavoenzyme [3]. The enzyme specifically modifies uracil²⁰ in tRNA.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Xing, F., Hiley, S.L., Hughes, T.R. and Phizicky, E.M. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. J. Biol. Chem. 279 (2004) 17850–17860. [DOI] [PMID: 14970222]
2.	Xing, F., Martzen, M.R. and Phizicky, E.M. A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RNA 8 (2002) 370–381. [PMID: 12003496]
3.	Rider, L.W., Ottosen, M.B., Gattis, S.G. and Palfey, B.A. Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction. J. Biol. Chem. 284 (2009) 10324–10333. [DOI] [PMID: 19139092]
4.	Kato, T., Daigo, Y., Hayama, S., Ishikawa, N., Yamabuki, T., Ito, T., Miyamoto, M., Kondo, S. and Nakamura, Y. A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. Cancer Res. 65 (2005) 5638–5646. [DOI] [PMID: 15994936]

[EC 1.3.1.91 created 2011]