ExplorEnz: EC 1.3.1.88

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1.3.1.88

Accepted name:

tRNA-dihydrouridine^16/17 synthase [NAD(P)⁺]

Reaction:

(1) 5,6-dihydrouracil¹⁶ in tRNA + NAD(P)⁺ = uracil¹⁶ in tRNA + NAD(P)H + H⁺
(2) 5,6-dihydrouracil¹⁷ in tRNA + NAD(P)⁺ = uracil¹⁷ in tRNA + NAD(P)H + H⁺

Other name(s):

Dus1p; tRNA-dihydrouridine synthase 1

Systematic name:

tRNA-5,6-dihydrouracil^16/17:NAD(P)⁺ oxidoreductase

Comments:

A flavoprotein. The enzyme specifically modifies uracil¹⁶ and uracil¹⁷ in tRNA.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Xing, F., Hiley, S.L., Hughes, T.R. and Phizicky, E.M. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. J. Biol. Chem. 279 (2004) 17850–17860. [DOI] [PMID: 14970222]
2.	Xing, F., Martzen, M.R. and Phizicky, E.M. A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RNA 8 (2002) 370–381. [PMID: 12003496]

[EC 1.3.1.88 created 2011]