| EC |
1.3.1.73 |
| Accepted name: |
1,2-dihydrovomilenine 19,20-reductase |
| Reaction: |
17-O-acetylnorajmaline + NADP+ = (2R)-1,2-dihydrovomilenine + NADPH + H+ |
|
For diagram of ajmaline, vinorine, vomilenine and raucaffricine biosynthesis, click here |
| Other name(s): |
1,2-dihydrovomilenine reductase; DHVR; RR4 (gene name); 17-O-acetylnorajmaline:NADP+ oxidoreductase |
| Systematic name: |
17-O-acetylnorajmaline:NADP+ 19,20-oxidoreductase |
| Comments: |
The enzyme, characterized from the plant Rauvolfia serpentina, participates in the ajmaline biosynthesis pathway. It has a much lower activity on vomilenine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Gao, S., von Schumann, G. and Stöckigt, J. A newly-detected reductase from Rauvolfia closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline. Planta Med. 68 (2002) 906–911. [DOI] [PMID: 12391554] |
| 2. |
Guo, J., Gao, D., Lian, J. and Qu, Y. De novo biosynthesis of antiarrhythmic alkaloid ajmaline. Nat. Commun. 15:457 (2024). [DOI] [PMID: 38212296] |
|
| [EC 1.3.1.73 created 2002, modified 2024] |
| |
|
| |
|
Printable version