The Enzyme Database

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Accepted name: 2′-hydroxyisoflavone reductase
Reaction: vestitone + NADP+ = 2′-hydroxyformononetin + NADPH + H+
For diagram of the biosynthesis of formononetin and derivatives, click here
Other name(s): NADPH:2′-hydroxyisoflavone oxidoreductase; isoflavone reductase; 2′,7-dihydroxy-4′,5′-methylenedioxyisoflavone reductase
Systematic name: vestitone:NADP+ oxidoreductase
Comments: In the reverse reaction, a 2′-hydroxyisoflavone is reduced to an isoflavanone; 2′-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 128449-69-4
1.  Tiemann, K., Hinderer, W. and Barz, W. Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum. FEBS Lett. 213 (1987) 324–328.
[EC created 1990]

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