| EC |
1.3.1.21 |
| Accepted name: |
7-dehydrocholesterol reductase |
| Reaction: |
cholesterol + NADP+ = cholesta-5,7-dien-3β-ol + NADPH + H+ |
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For diagram of sterol ring b, c, D modification, click here |
| Other name(s): |
DHCR7 (gene name); 7-DHC reductase; 7-dehydrocholesterol dehydrogenase/cholesterol oxidase; Δ7-sterol reductase |
| Systematic name: |
cholesterol:NADP+ Δ7-oxidoreductase |
| Comments: |
The enzyme is part of the cholesterol biosynthesis pathway. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 9080-21-1 |
| References: |
| 1. |
Dempsey, M.E., Seaton, J.D., Schroepfer, G.J. and Trockman, R.W. The intermediary role of Δ5,7-cholestadien-3β-ol in cholesterol biosynthesis. J. Biol. Chem. 239 (1964) 1381–1387. [PMID: 14189869] |
| 2. |
Moebius, F.F., Fitzky, B.U., Lee, J.N., Paik, Y.K. and Glossmann, H. Molecular cloning and expression of the human Δ7-sterol reductase. Proc. Natl. Acad. Sci. USA 95 (1998) 1899–1902. [DOI] [PMID: 9465114] |
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| [EC 1.3.1.21 created 1972, modified 2013] |
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