The Enzyme Database

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Accepted name: dihydropyrimidine dehydrogenase (NADP+)
Reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+
For diagram of pyrimidine catabolism, click here
Other name(s): dihydrothymine dehydrogenase; dihydrouracil dehydrogenase (NADP+); 4,5-dihydrothymine: oxidoreductase; DPD; DHPDH; dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate); DHU dehydrogenase; hydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase (NADP)
Systematic name: 5,6-dihydrouracil:NADP+ 5-oxidoreductase
Comments: Also acts on dihydrothymine.
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9029-01-0
1.  Fritzson, P. Properties and assay of dihydrouracil dehydrogenase of rat liver. J. Biol. Chem. 235 (1960) 719–725. [PMID: 13825299]
2.  Shiotani, T. and Weber, G. Purification and properties of dihydrothymine dehydrogenase from rat liver. J. Biol. Chem. 256 (1981) 219–224. [PMID: 7451435]
[EC created 1961, modified 1986]

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