| EC |
1.3.1.15 |
| Accepted name: |
dihydroorotate dehydrogenase (NADP+) |
| Reaction: |
(S)-dihydroorotate + NADP+ = orotate + NADPH + H+ |
| Other name(s): |
orotate reductase; dihydro-orotic dehydrogenase; L-5,6-dihydro-orotate:NAD+ oxidoreductase; orotate reductase (NADPH) |
| Systematic name: |
(S)-dihydroorotate:NADP+ oxidoreductase |
| Comments: |
Binds FMN and FAD [2]. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor . |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 37255-27-9 |
| References: |
| 1. |
Taylor, W.H., Taylor, M.L. and Eames, D.F. Two functionally different dihydroorotic dehydrogenases in bacteria. J. Bacteriol. 91 (1966) 2251–2256. [PMID: 4380263] |
| 2. |
Udaka, S. and Vennesland, B. Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase. J. Biol. Chem. 237 (1962) 2018–2024. [PMID: 13923427] |
|
| [EC 1.3.1.15 created 1972, modified 2011] |
| |
|
| |
|
Printable version