ExplorEnz: EC 1.3.1.115

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1.3.1.115

Accepted name:

3-oxocholoyl-CoA 4-desaturase

Reaction:

(1) 7α,12α-dihydroxy-3-oxochol-24-oyl-CoA + NAD⁺ = 7α,12α-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H⁺
(2) 7α-hydroxy-3-oxochol-24-oyl-CoA + NAD⁺ = 7α-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H⁺

Glossary:

7α,12α-dihydroxy-3-oxochol-24-oyl-CoA = 3-oxocholoyl-CoA
7α-hydroxy-3-oxochol-24-oyl-CoA = 3-oxochenodeoxycholoyl-CoA

Other name(s):

baiCD (gene name); 3-oxo-choloyl-CoA dehydrogenase

Systematic name:

3-oxocholoyl-CoA Δ⁴-oxidoreductase

Comments:

Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7α-dehydroxylation pathway. The enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7β anomers. cf. EC 1.3.1.116, 7β-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Kang, D.J., Ridlon, J.M., Moore, D.R., 2nd, Barnes, S. and Hylemon, P.B. Clostridium scindens baiCD and baiH genes encode stereo-specific 7α/7β-hydroxy-3-oxo-Δ⁴-cholenoic acid oxidoreductases. Biochim. Biophys. Acta 1781 (2008) 16–25. [PMID: 18047844]

[EC 1.3.1.115 created 2018]