EC |
1.3.1.113 |
Accepted name: |
(4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase |
Reaction: |
a [(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl phosphate + NADP+ = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + NADPH + H+ |
Other name(s): |
bprA (gene name); scbC (gene name) |
Systematic name: |
[(3S,4R)-4-alkanoyl-5-oxooxolan-3-yl]methyl-phosphate:NADP+ oxidoreductase |
Comments: |
The enzyme, characterized from the bacteria Streptomyces griseus and Streptomyces coelicolor, is involved in the biosynthesis of γ-butyrolactone autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
References: |
1. |
Kato, J.Y., Funa, N., Watanabe, H., Ohnishi, Y. and Horinouchi, S. Biosynthesis of γ-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces. Proc. Natl. Acad. Sci. USA 104 (2007) 2378–2383. [DOI] [PMID: 17277085] |
2. |
Biarnes-Carrera, M., Lee, C.K., Nihira, T., Breitling, R. and Takano, E. Orthogonal regulatory circuits for Escherichia coli based on the γ-butyrolactone system of Streptomyces coelicolor. ACS Synth. Biol. 7 (2018) 1043–1055. [PMID: 29510026] |
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[EC 1.3.1.113 created 2017] |
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