| EC |
1.21.99.3 |
| Accepted name: |
thyroxine 5-deiodinase |
| Reaction: |
3,3′,5′-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor |
| Other name(s): |
diiodothyronine 5′-deiodinase (ambiguous); iodothyronine 5-deiodinase; iodothyronine inner ring monodeiodinase; type III iodothyronine deiodinase |
| Systematic name: |
3,3′,5′-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating) |
| Comments: |
The enzyme activity has only been demonstrated in the direction of 5-deiodination. This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 74506-30-2 |
| References: |
| 1. |
Chopra, I.J. and Teco, G.N.C. Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines. Endocrinology 110 (1982) 89–97. [DOI] [PMID: 7053997] |
| 2. |
Körhle, J. Iodothyronine deiodinases. Methods Enzymol. 347 (2002) 125–167. [PMID: 11898402] |
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| [EC 1.21.99.3 created 2003 as EC 1.97.1.11, transferred 2015 to EC 1.21.99.3] |
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