Accepted name: columbamine oxidase
Reaction: 2 columbamine + O2 = 2 berberine + 2 H2O
Other name(s): berberine synthase
Systematic name: columbamine:oxygen oxidoreductase (cyclizing)
Comments: An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine.
1.  Rueffer, M. and Zenk, M.H. Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis. Tetrahedron Lett. 26 (1985) 201–202.
[EC created 1989 as EC, transferred 2002 to EC]

Data © 2001–2020 IUBMB
Web site © 2005–2020 Andrew McDonald