ExplorEnz: EC 1.21.3.11

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1.21.3.11

Accepted name:

precondylocarpine acetate synthase

Reaction:

stemmadenine acetate + O₂ = precondylocarpine acetate + H₂O₂

For diagram of biosythesis of stemmadenine and related alkaloids, click here

Other name(s):

PAS (gene name)

Systematic name:

stemmadenine acetate:oxygen oxidoreductase

Comments:

The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a pathway that leads to the production of a number of monoterpene alkaloids, as well as the bisindole alkaloids vinblastine and vincristine, which are used as anticancer drugs. The enzyme is similar to berberine bridge enzymes such as EC 1.21.3.3, reticuline oxidase, and requires an FAD cofactor.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Caputi, L., Franke, J., Farrow, S.C., Chung, K., Payne, R.ME., Nguyen, T.D., Dang, T.T., Soares Teto Carqueijeiro, I., Koudounas, K., Duge de Bernonville, T., Ameyaw, B., Jones, D.M., Vieira, I.JC., Courdavault, V. and O'Connor, S.E. Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle. Science 360 (2018) 1235–1239. [DOI] [PMID: 29724909]

[EC 1.21.3.11 created 2024]