| EC |
1.21.3.10 |
| Accepted name: |
hercynylcysteine S-oxide synthase |
| Reaction: |
hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
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For diagram of ergothioneine and ovothiol biosynthesis, click here |
| Glossary: |
hercynine = Nα,Nα,Nα-trimethyl-L-histidine |
| Other name(s): |
Egt1; Egt-1 |
| Systematic name: |
hercynine,L-cysteine:oxygen [S-(hercyn-2-yl)-L-cysteine S-oxide-forming] |
| Comments: |
Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nα-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Pluskal, T., Ueno, M. and Yanagida, M. Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system. PLoS One 9:e97774 (2014). [DOI] [PMID: 24828577] |
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| [EC 1.21.3.10 created 2015 as 1.14.99.51, transferred 2022 to EC 1.21.3.10] |
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