ExplorEnz: EC 1.2.3.15

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1.2.3.15

Accepted name:

(methyl)glyoxal oxidase

Reaction:

(1) glyoxal + H₂O + O₂ = glyoxylate + H₂O₂
(2) 2-oxopropanal + H₂O + O₂ = pyruvate + H₂O₂

Glossary:

2-oxopropanal = methylglyoxal

Other name(s):

glx1 (gene name); glx2 (gene name)

Systematic name:

(methyl)glyoxal:oxygen oxidoreductase

Comments:

The enzyme, originally characterized from the white rot fungus Phanerochaete chrysosporium, utilizes a free radical-coupled copper complex for catalysis.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Kersten, P.J. and Kirk, T.K. Involvement of a new enzyme, glyoxal oxidase, in extracellular H₂O₂ production by Phanerochaete chrysosporium. J. Bacteriol. 169 (1987) 2195–2201. [DOI] [PMID: 3553159]
2.	Kersten, P.J. and Cullen, D. Cloning and characterization of cDNA encoding glyoxal oxidase, a H₂O₂-producing enzyme from the lignin-degrading basidiomycete Phanerochaete chrysosporium. Proc. Natl. Acad. Sci. USA 90 (1993) 7411–7413. [DOI] [PMID: 8346264]
3.	Kersten, P.J., Witek, C., vanden Wymelenberg, A. and Cullen, D. Phanerochaete chrysosporium glyoxal oxidase is encoded by two allelic variants: structure, genomic organization, and heterologous expression of glx1 and glx2. J. Bacteriol. 177 (1995) 6106–6110. [DOI] [PMID: 7592374]
4.	Whittaker, M.M., Kersten, P.J., Nakamura, N., Sanders-Loehr, J., Schweizer, E.S. and Whittaker, J.W. Glyoxal oxidase from Phanerochaete chrysosporium is a new radical-copper oxidase. J. Biol. Chem. 271 (1996) 681–687. [DOI] [PMID: 8557673]

[EC 1.2.3.15 created 2016]