ExplorEnz: EC 1.2.3.1

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1.2.3.1

Accepted name:

aldehyde oxidase

Reaction:

an aldehyde + H₂O + O₂ = a carboxylate + H₂O₂

Other name(s):

quinoline oxidase; retinal oxidase

Systematic name:

aldehyde:oxygen oxidoreductase

Comments:

Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme, retinal oxidase (formerly EC 1.2.3.11) [5,7].

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9029-07-6

References:

1.	Gordon, A.H., Green, D.E. and Subrahmanyan, V. Liver aldehyde oxidase. Biochem. J. 34 (1940) 764–774. [PMID: 16747217]
2.	Knox, W.E. The quinine-oxidizing enzyme and liver aldehyde oxidase. J. Biol. Chem. 163 (1946) 699–711. [PMID: 20985642]
3.	Mahler, H.R., Mackler, B., Green, D.E. and Bock, R.M. Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein. J. Biol. Chem. 210 (1954) 465–480. [PMID: 13201608]
4.	Krenitsky, T.A., Neil, S.M., Elion, G.B. and Hitchings, G.H. A comparison of the specificities of xanthine oxidase and aldehyde oxidase. Arch. Biochem. Biophys. 150 (1972) 585–599. [DOI] [PMID: 5044040]
5.	Tomita, S., Tsujita, M. and Ichikawa, Y. Retinal oxidase is identical to aldehyde oxidase. FEBS Lett. 336 (1993) 272–274. [DOI] [PMID: 8262244]
6.	Yoshihara, S. and Tatsumi, K. Purification and characterization of hepatic aldehyde oxidase in male and female mice. Arch. Biochem. Biophys. 338 (1997) 29–34. [DOI] [PMID: 9015384]
7.	Huang, D.-Y., Furukawa, A. and Ichikawa, Y. Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. Arch. Biochem. Biophys. 364 (1999) 264–272. [DOI] [PMID: 10190983]
8.	Uchida, H., Kondo, D., Yamashita, A., Nagaosa, Y., Sakurai, T., Fujii, Y., Fujishiro, K., Aisaka, K. and Uwajima, T. Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690. FEMS Microbiol. Lett. 229 (2003) 31–36. [DOI] [PMID: 14659539]

[EC 1.2.3.1 created 1961, modified 2002, modified 2004, modified 2012]