ExplorEnz: EC 1.2.1.78

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1.2.1.78

Accepted name:

2-formylbenzoate dehydrogenase

Reaction:

2-formylbenzoate + NAD⁺ + H₂O = o-phthalic acid + NADH + H⁺

Glossary:

o-phthalic acid = benzene-1,2-dicarboxylic acid
2-formylbenzoate = 2-carboxybenzaldehyde

Other name(s):

2-carboxybenzaldehyde dehydrogenase; 2CBAL dehydrogenase; PhdK

Systematic name:

2-formylbenzoate:NAD⁺ oxidoreductase

Comments:

The enzyme is involved in phenanthrene degradation.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Iwabuchi, T. and Harayama, S. Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7. J. Bacteriol. 179 (1997) 6488–6494. [DOI] [PMID: 9335300]
2.	Kiyohara, H., Nagao, K. and Yano, K. Isolation and some properties of NAD-linked 2-carboxybenzaldehyde dehydrogenase in Alcaligenes faecalis AFK 2 grown on phenanthrene. J. Gen. Appl. Microbiol. 27 (1981) 443–455.

[EC 1.2.1.78 created 2010]