Accepted name: pyruvate dehydrogenase (NADP+)
Reaction: pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH
Glossary: methyl viologen = 1,1′-dimethyl-4,4′-bipyridine-1,1′-diium
Systematic name: pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
Comments: The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen.
1.  Inui, H., Miyatake, K., Nakano, Y. and Kitaoka, S. Occurrence of oxygen-sensitive, NADP +-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis. J. Biochem. (Tokyo) 96 (1984) 931–934. [PMID: 6438078]
2.  Inui, H., Ono, K., Miyatake, K., Nakano, Y. and Kitaoka, S. Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis. J. Biol. Chem. 262 (1987) 9130–9135. [PMID: 3110154]
[EC created 1989]