| EC |
1.2.1.23 |
| Accepted name: |
2-oxoaldehyde dehydrogenase (NAD+) |
| Reaction: |
a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo carboxylate + NADH + H+ |
| Other name(s): |
α-ketoaldehyde dehydrogenase; methylglyoxal dehydrogenase; NAD+-linked α-ketoaldehyde dehydrogenase; 2-ketoaldehyde dehydrogenase; NAD+-dependent α-ketoaldehyde dehydrogenase |
| Systematic name: |
2-oxoaldehyde:NAD+ 2-oxidoreductase |
| Comments: |
Not identical with EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37250-91-2 |
| References: |
| 1. |
Monder, C. α-Keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate. J. Biol. Chem. 242 (1967) 4603–4609. [PMID: 4383524] |
| 2. |
Ray, M. and Ray, S. On the interaction of nucleotides and glycolytic intermediates with NAD-linked α-ketoaldehyde dehydrogenase. J. Biol. Chem. 257 (1982) 10571–10574. [PMID: 7107626] |
| 3. |
Ray, S. and Ray, M. Purification and characterization of NAD and NADP-linked α-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate. J. Biol. Chem. 257 (1982) 10566–10570. [PMID: 7107625] |
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| [EC 1.2.1.23 created 1972, modified 1986] |
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