ExplorEnz: EC 1.2.1.100

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1.2.1.100

Accepted name:

5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase

Reaction:

5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD⁺ + H₂O = 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H⁺

For diagram of pyridoxal catabolism, click here

Other name(s):

mlr6793 (locus name)

Systematic name:

5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD⁺ 5-oxidoreductase

Comments:

The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B₆).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Lee, Y.C., Nelson, M.J. and Snell, E.E. Enzymes of vitamin B₆ degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase. J. Biol. Chem. 261 (1986) 15106–15111. [PMID: 3533936]
2.	Yokochi, N., Yoshikane, Y., Matsumoto, S., Fujisawa, M., Ohnishi, K. and Yagi, T. Gene identification and characterization of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD⁺-dependent dismutase. J. Biochem. 145 (2009) 493–503. [DOI] [PMID: 19218190]
3.	Mugo, A.N., Kobayashi, J., Mikami, B., Yoshikane, Y., Yagi, T. and Ohnishi, K. Crystal structure of 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase, an NAD(+)-dependent dismutase from Mesorhizobium loti. Biochem. Biophys. Res. Commun. 456 (2015) 35–40. [DOI] [PMID: 25446130]

[EC 1.2.1.100 created 2018]