| EC |
1.17.99.6 |
| Accepted name: |
epoxyqueuosine reductase |
| Reaction: |
queuosine34 in tRNA + acceptor + H2O = epoxyqueuosine34 in tRNA + reduced acceptor |
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For diagram of queuine biosynthesis, click here |
| Glossary: |
queuine = base Q = 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-1,7-dihydropyrrolo[3,2-e]pyrimidin-4-one
epoxyqueine = base oQ |
| Other name(s): |
oQ reductase; queG (gene name); queH (gene name) |
| Systematic name: |
queuosine34 in tRNA:acceptor oxidoreductase |
| Comments: |
This enzyme catalyses the last step in the bacterial biosynthetic pathway to queuosine, the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Miles, Z.D., McCarty, R.M., Molnar, G. and Bandarian, V. Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification. Proc. Natl. Acad. Sci. USA 108 (2011) 7368–7372. [DOI] [PMID: 21502530] |
| 2. |
Zallot, R., Ross, R., Chen, W.H., Bruner, S.D., Limbach, P.A. and De Crecy-Lagard, V. Identification of a novel epoxyqueuosine reductase family by comparative genomics. LID - 10.1021/acschembio.6b01100 [doi. ACS Chem. Biol. (2017) . [DOI] [PMID: 28128549] |
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| [EC 1.17.99.6 created 2014] |
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