The Enzyme Database

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Accepted name: uracil/thymine dehydrogenase
Reaction: (1) uracil + H2O + acceptor = barbiturate + reduced acceptor
(2) thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor
For diagram of pyrimidine catabolism, click here
Other name(s): uracil oxidase; uracil-thymine oxidase; uracil dehydrogenase
Systematic name: uracil:acceptor oxidoreductase
Comments: Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC (barbiturase) and EC (N-malonylurea hydrolase). Mammals, plants and other microorganisms utilize the reductive pathway, comprising EC [dihydrouracil dehydrogenase (NAD+)] or EC [dihydropyrimidine dehydrogenase (NADP+)], EC (dihydropyrimidinase) and EC (β-ureidopropionase), with the ultimate degradation products being an L-amino acid, NH3 and CO2 [5].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9029-00-9
1.  Hayaishi, O. and Kornberg, A. Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes. J. Biol. Chem. 197 (1952) 717–723. [PMID: 12981104]
2.  Wang, T.P. and Lampen, J.O. Metabolism of pyrimidines by a soil bacterium. J. Biol. Chem. 194 (1952) 775–783. [PMID: 14927671]
3.  Wang, T.P. and Lampen, J.O. Uracil oxidase and the isolation of barbituric acid from uracil oxidation. J. Biol. Chem. 194 (1952) 785–791. [PMID: 14927672]
4.  Lara, F.J.S. On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations. J. Bacteriol. 64 (1952) 279–285. [PMID: 14955523]
5.  Soong, C.L., Ogawa, J. and Shimizu, S. Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase. Biochem. Biophys. Res. Commun. 286 (2001) 222–226. [DOI] [PMID: 11485332]
[EC created 1961 as EC, transferred 1984 to EC, transferred 2006 to EC]

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