EC |
1.17.99.2 |
Accepted name: |
ethylbenzene hydroxylase |
Reaction: |
ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor |
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For diagram of reaction, click here |
Other name(s): |
ethylbenzene dehydrogenase; ethylbenzene:(acceptor) oxidoreductase |
Systematic name: |
ethylbenzene:acceptor oxidoreductase |
Comments: |
Involved in the anaerobic catabolism of ethylbenzene by denitrifying bacteria. Ethylbenzene is the preferred substrate; the enzyme from some strains oxidizes propylbenzene, 1-ethyl-4-fluorobenzene, 3-methylpent-2-ene and ethylidenecyclohexane. Toluene is not oxidized. p-Benzoquinone or ferrocenium can act as electron acceptor. Contains molybdopterin, [4Fe-4S] clusters and heme b. |
Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 372947-56-3 |
References: |
1. |
Kniemeyer, O. and Heider, J. Ethylbenzene dehydrogenase, a novel hydrocarbon-oxidising molybdenum/iron-sulfur/heme enzyme. J. Biol. Chem. 276 (2001) 21381–21386. [DOI] [PMID: 11294876] |
2. |
Johnson, H.A., Pelletier, D.A. and Spormann, A.M. Isolation and characterisation of anaerobic ethylbenzene dehydrogenase, a novel Mo-Fe-S enzyme. J. Bacteriol. 183 (2001) 4536–4542. [DOI] [PMID: 11443088] |
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[EC 1.17.99.2 created 2001] |
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