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Your query returned 1 entry. Printable version
EC | 1.17.7.4 | ||||||||||||
Accepted name: | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase | ||||||||||||
Reaction: | (1) 3-methylbut-3-en-1-yl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ (2) prenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ |
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For diagram of Non-Mevalonate terpenoid biosynthesis, click here | |||||||||||||
Glossary: | isopentenyl = 3-methylbut-3-en-1-yl prenyl = 3-methylbut-2-en-1-yl |
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Other name(s): | isopentenyl-diphosphate:NADP+ oxidoreductase; LytB; (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; HMBPP reductase; IspH; LytB/IspH; isopentenyl-diphosphate:ferredoxin oxidoreductase | ||||||||||||
Systematic name: | 3-methylbut-3-en-1-yl-diphosphate:ferredoxin oxidoreductase | ||||||||||||
Comments: | An iron-sulfur protein that contains an unusual [4Fe-4S] cluster [5,6]. This enzyme forms a system with a ferredoxin or a flavodoxin and an NAD(P)H-dependent reductase. This is the last enzyme in the non-mevalonate pathway for isoprenoid biosynthesis. This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most bacteria and in plant chloroplasts. The enzyme acts in the reverse direction, producing a 5:1 mixture of 3-methylbut-3-en-1-yl diphosphate and prenyl diphosphate. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 512789-14-9 | ||||||||||||
References: |
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