ExplorEnz: EC 1.16.2.1

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1.16.2.1

Accepted name:

iron—cytochrome-c reductase

Reaction:

ferrocytochrome c + Fe³⁺ = ferricytochrome c + Fe²⁺

Other name(s):

iron-cytochrome c reductase; mtrC (gene name); omcA (gene name); omcB (gene name)

Systematic name:

ferrocytochrome-c:Fe³⁺ oxidoreductase

Comments:

The MtrC and OmcA proteins of the bacterium Shewanella oneidensis MR-1 are decaheme c-type cytochromes that reduce iron oxides extracellularly, passing the electrons to MtrA, another decaheme c-type cytochrome located in the periplasm.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37256-52-3

References:

1.	Beliaev, A.S., Saffarini, D.A., McLaughlin, J.L. and Hunnicutt, D. MtrC, an outer membrane decahaem c cytochrome required for metal reduction in Shewanella putrefaciens MR-1. Mol. Microbiol. 39 (2001) 722–730. [DOI] [PMID: 11169112]
2.	Myers, C.R. and Myers, J.M. Cell surface exposure of the outer membrane cytochromes of Shewanella oneidensis MR-1. Lett. Appl. Microbiol. 37 (2003) 254–258. [DOI] [PMID: 12904229]
3.	Lower, B.H., Shi, L., Yongsunthon, R., Droubay, T.C., McCready, D.E. and Lower, S.K. Specific bonds between an iron oxide surface and outer membrane cytochromes MtrC and OmcA from Shewanella oneidensis MR-1. J. Bacteriol. 189 (2007) 4944–4952. [DOI] [PMID: 17468239]
4.	Hartshorne, R.S., Reardon, C.L., Ross, D., Nuester, J., Clarke, T.A., Gates, A.J., Mills, P.C., Fredrickson, J.K., Zachara, J.M., Shi, L., Beliaev, A.S., Marshall, M.J., Tien, M., Brantley, S., Butt, J.N. and Richardson, D.J. Characterization of an electron conduit between bacteria and the extracellular environment. Proc. Natl. Acad. Sci. USA 106 (2009) 22169–22174. [DOI] [PMID: 20018742]
5.	Mitchell, A.C., Peterson, L., Reardon, C.L., Reed, S.B., Culley, D.E., Romine, M.R. and Geesey, G.G. Role of outer membrane c-type cytochromes MtrC and OmcA in Shewanella oneidensis MR-1 cell production, accumulation, and detachment during respiration on hematite. Geobiology 10 (2012) 355–370. [DOI] [PMID: 22360295]
6.	Jing, X., Wu, Y., Shi, L., Peacock, C.L., Ashry, N.M., Gao, C., Huang, Q. and Cai, P. Outer membrane c-type cytochromes OmcA and MtrC play distinct roles in enhancing the attachment of Shewanella oneidensis MR-1 cells to goethite. Appl. Environ. Microbiol. 86 (2020) . [DOI] [PMID: 32978123]

[EC 1.16.2.1 created 1972 as EC 1.9.99.1, transferred 2014 to EC 1.9.98.1, transferred 2024 to EC 1.16.2.1 ]